Gizzelle's first release was the acclaimed "Baby Please Don't Go" 45, which debuted in 2005. The record received widespread critical acclaim within both the Rock 'n' Roll and Soul scenes and is now a sought-after collectible, selling for anywhere between $250 and $500. Gizzelle's first full-length album, Devil or Angel, was released in 2006, featuring a mix of 1950s-60s R&B, 1960s Soul, and Rock 'n' Roll.

In 2010, Gizzelle released the highly regarded "I'm a Good Woman" 45, which again received critical acclaim within the Rock 'n' Roll and Soul communities. The record sold out within two months and has since become a collectible item. Later that year, Gizzelle's Rhythm & Soul album was released on both CD and vinyl. The vinyl edition sold out within a month, and the CD has become one of the label's best-selling releases.

Gizzelle performs late 1950s blues, rhythm and blues, and early 1960s soul. Her powerful voice is considered one of the greatest on the scene.